Fig. 2

Fig. 2 Detection of cardiac dilation and inflammation in zebrafish Dsp mutants.

A–A′-A″ Heart morphology analysis of wild type and -ab mutant zebrafish embryos using a myocardial-specific transgene Tg(tg:EGFP-myl7:EGFP)^ia300 identified a global dilation of both chambers in -ab mutants. All embryos are at 3 dpf, in lateral view. Sample size: n = 22 ± 1. R.R relative ratio. Error bars: SEM. ****p < 0.0001. Test: Unpaired t-test. B–B′–B″: Cells expressing the inflammatory marker L-plastin are more abundant in -ab mutants, compared to WT. All embryos are at 3 dpf, in lateral view, anterior to the left. Sample size: n = 6. R.I. relative intensity. Error bars: SEM. **p < 0.01. Test: Unpaired t-test.