FIGURE

Figure 6

ID

ZDB-FIG-231204-41

Publication

Serrano et al., 2023 - Genetic model of UBA5 deficiency highlights the involvement of both peripheral and central nervous systems and identifies widespread mitochondrial abnormalities

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Figure 6

Ultrastructural analysis of the cerebellum at 14 dpf shows abnormal findings in uba5^ex1s/ex1s animals. Membranous swirls (ii, ii′), membrane whorls inside neurons that are indicative of mitochondrial degradation (iv, iv′) and cytoplasmatic condensation (vi, vi′) are observed in uba5^ex1s/ex1s mutants (arrowheads) compared to uba5^+/+ (i, iii, v). (ii′, iv′, vi′). A higher magnification view of boxed areas.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	uba5^mnu11/mnu11 (TU)
Observed In:	cerebellum mitochondrion cerebellum neuron
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

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