M-mode revealed cardiac physiological functions after asb5a/asb5b inactivation. The 10 s M-modes clearly displayed various physiological and functional indicators. (A) Compared with the WT group, the asb5a−/−:asb5b-ATGmo double-knockout group showed prolonged HP, SI, and DI. (B) Heart rate statistical results. Compared with the WT group, heart rate in the single-gene-knockout group was significantly increased, whereas heart rate in the double-gene-knockout group was significantly decreased. (C) Statistical results of HP. Compared with the WT group, HP in the single-gene-knockout group was significantly shortened, whereas HP in the double-gene-knockout group was significantly increased. (D) Statistical results of SI. Compared with the WT group, there was no significant change in SI in the single-gene-knockout group, whereas SI in the double-gene-knockout group was significantly prolonged. (E) Statistical results of DI. Compared with the WT group, DI in the single-gene-knockout group was significantly shortened, whereas DI in the double-gene-knockout group was significantly prolonged. HP: heart period; SI: systolic interval; DI: diastolic interval; DD: diastolic diameter; SD: systolic diameter. Plotted data represent means ± standard error of the mean (SEM; n = 30). ns p > 0.05; * p < 0.05; ** p < 0.01; *** p < 0.001.
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