FIGURE

FIGURE 4

ID

ZDB-FIG-230916-12

Publication

DeMoya et al., 2023 - Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development

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FIGURE 4

RNAseq reveals cardiac contraction and conduction is altered in MZsap130a(A) Representative images of Tg(myl7:EGFP) and MZsap130a;Tg(myl7:EGFP) embryos collected for whole embryo RNAseq at 36hpf. (B) Volcano plot of 36hpf whole embryo RNAseq data. (C) Heatmap of sarcomere and conduction genes (Supplementary Figure S6) at 36hpf from whole embryos. (D) DAVID functional annotation cluster 8 from downregulated genes in MZsap130a, showing DAVID calculated p-values. (E) Heatmap of 48hpf heart tissue RNAseq data for the same genes found in panel C. V and A are ventricle and atria, respectively. Scale bar 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sap130a^pt32a/pt32a; twu34Tg
Observed In:	cardiac ventricle
Stage:	Prim-25

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol