FIGURE

Fig. 4

ID

ZDB-FIG-230115-61

Publication

Brandt et al., 2021 - Ablation of mpeg+ Macrophages Exacerbates mfrp-Related Hyperopia

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Fig. 4

Macrophage ablation exacerbated hyperopia in mfrp^–/– zebrafish. (A) Representative SD-OCT B-scans from the center of mfrp^+/^–; mpeg1:NTR-eYFP⁺ eyes and their mfrp^–^/^–; mpeg1:NTR-eYFP⁺ siblings with or without MTZ treatment. (B) Eye size metrics of mfrp⁺^/^–; mpeg1:NTR-eYFP⁺ and mfrp^–^/^–; mpeg1:NTR-eYFP⁺ fish with or without MTZ treatment. (C) Axial length normalized to body length and lens diameter. (D) Relative refractive error. Two-way ANOVA was used for statistical analysis. P values are shown from Tukey's multiple comparisons for post hoc analysis. Error bars represent standard deviation. Red bars indicate statistical significance due to MTZ treatment. ^*P < 0.05, ^*^*P < 0.01, ^**^*P < 0.001, ^***^*P < 0.0001. For mfrp⁺^/^– untreated, n = 11; for mfrp⁺^/^– MTZ treated, n = 14; for mfrp^–^/^– untreated, n = 15; for mfrp^–^/^– MTZ treated, n = 9.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mfrp^mw78/+; w202Tg/w202Tg mfrp^mw78/mw78; w202Tg/w202Tg
Condition:	chemical treatment by environment: metronidazole
Observed In:	eye post-embryonic eye morphogenesis whole organism
Stage:	Days 45-89

Phenotype Detail

Acknowledgments

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