FIGURE

Figure 2

ID

ZDB-FIG-230110-118

Publication

Lai et al., 2022 - Deficiency of Adipose Triglyceride Lipase Induces Metabolic Syndrome and Cardiomyopathy in Zebrafish

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Figure 2

Defective Atgl led to energy imbalance and hyperlipidemia/hyperglycemia in ALKO larvae/adults. (A) Whole-mount Oil Red O staining of control (Heterozygous Tg (Cmlc2-GFP-U6-gRNA^atgl-4X)) and ALKO at 21 dpf. Scale bar: 100 μm. Percentages of control and ALKO larvae with no, weak, moderate, and strong levels of lipidemia at 21 dpf were presented in the middle panel. (B) Molecule analysis of ALKO at 45 dpf represented an upregulation of the lipogenic genes peroxisome proliferator-activated receptor gamma (ppar-γ), sterol regulatory element binding transcription factor 1 (srebp1), sterol regulatory element binding transcription factor 2 (srebp2), fatty acid synthase (fasn), acetyl-CoA carboxylase alpha (acaca), and carbohydrate-responsive element-binding protein (chrebp). Values of ppar-y = 1.9410 ± 0.0608, srebp1 = 2.2597 ± 0.0562, srebp2 = 1.7098 ± 0.0290, fasn = 1.4120 ± 0.0356, acaca = 1.6749 ± 0.0640, and chrebp = 2.2168 ± 0.1528 in ALKO group. Statistically significant differences from the controls are indicated by * p < 0.05, ** p < 0.01, and *** p < 0.001.

Expression Data

Genes:	acaca fasn mlxip pparg srebf1 srebf2 (all 6)
Fish:	WT ym118Tg; ym119Tg
Anatomical Term:	whole organism
Stage:	Days 45-89

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ym118Tg; ym119Tg
Observed In:	caudal vein lipid dorsal aorta lipid visceral fat lipid whole organism
Stage Range:	Days 21-29 to Days 45-89

Phenotype Detail

Acknowledgments

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