Gene
fasn
- ID
- ZDB-GENE-030131-7802
- Name
- fatty acid synthase
- Symbol
- fasn Nomenclature History
- Previous Names
-
- FAS (1)
- fj34h12
- wu:fj34h12
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Acts upstream of or within response to (R)-carnitine. Is expressed in gut; liver; male organism; and muscle. Orthologous to human FASN (fatty acid synthase).
- Genome Resources
- Note
-
Transcripts from ENSDARG00000087657 in Ensembl GRCz11 are associated with ccdc57 and fasn. fasn-202 (ENSDART00000124982) should be associated with ccdc57. Other transcripts belong with fasn. Alternate gene (haplotype) in GRCz11 is ENSDARG00000113553.
- Comparative Information
-
- All Expression Data
- 67 figures from 59 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018201 | Beta-ketoacyl synthase, active site |
| Domain | IPR001031 | Thioesterase |
| Domain | IPR009081 | Phosphopantetheine binding ACP domain |
| Domain | IPR013968 | Polyketide synthase, ketoreductase domain |
| Domain | IPR014030 | Beta-ketoacyl synthase-like, N-terminal |
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Domain Details Per Protein
| Protein | Length | ACP-like superfamily | Acyl transferase/acyl hydrolase/lysophospholipase | Acyl transferase domain | Acyl transferase domain superfamily | Alpha/Beta hydrolase fold | Beta-ketoacyl synthase, active site | Beta-ketoacyl synthase, C-terminal | Beta-ketoacyl synthase-like, N-terminal | Fatty acid synthase, pseudo-KR domain | GroES-like superfamily | Malonyl-CoA ACP transacylase, ACP-binding | NAD(P)-binding domain superfamily | Phosphopantetheine attachment site | Phosphopantetheine binding ACP domain | Polyketide and Nonribosomal Peptide Biosynthesis Enzymes | Polyketide/metazoan fatty acid synthase, dehydratase domain | Polyketide synthase, beta-ketoacyl synthase domain | Polyketide synthase, C-terminal extension | Polyketide synthase, dehydratase domain | Polyketide synthase, dehydratase domain, N-terminal | Polyketide synthase, dehydratase domain superfamily | Polyketide synthase, enoylreductase domain | Polyketide synthase, ketoreductase domain | Polyketide synthase, phosphopantetheine-binding domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Thioesterase | Thiolase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F5V3
|
2514 | |||||||||||||||||||||||||||
|
UniProtKB:F8W3U6
|
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UniProtKB:A0A8M9Q0T1
|
724 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-13L14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-105J12 | ZFIN Curated Data | |
| Encodes | EST | fj34h12 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306806 (1) | 10039 nt | ||
| Genomic | GenBank:CU137725 (1) | 154486 nt | ||
| Polypeptide | UniProtKB:E7F5V3 (2) | 2514 aa |
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):
- Jia, J.Y., Chen, G.H., Shu, T.T., Lou, Q.Y., Jin, X., He, J.Y., Xiao, W.H., Zhai, G., Yin, Z. (2024) Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish. Zoological research. 45:355366355-366
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Wang, X., Li, X., Wang, Y., Ren, Z., Du, X., Gao, J., Ji, G., Liu, Z. (2024) Nkx1.2 deletion decreases fat production in zebrafish. Obesity (Silver Spring, Md.). 32(7):1315-1328
- Yinger, R.V., Evangelisto, C.J., Tucker, N.C., Billingsley, J.M., Clair, S.L.S. (2024) β-Estradiol Supplementation Regulates Cholesterol Synthesis Independent of Unsaturated Fat Consumption in Adult Zebrafish. Zebrafish. 21:223230223-230
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
- Awasthi, N., Ward, A.C., Liongue, C. (2023) Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth. Frontiers in bioscience (Landmark edition). 28:187187
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