FIGURE

Fig. 2

ID

ZDB-FIG-221214-55

Publication

Liu et al., 2022 - Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia

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Fig. 2

Seahorse-specific mutation of the tlx1 gene. Seahorse-specific mutation of the <bold><italic>tlx1</italic></bold> gene.

a Schematic diagram of the involved genes during spleen growth and morphogenesis (modified from previous studies¹⁸). Red color Tlx1, the sequence-specific variation in seahorses; RA, retinoic acid. b Gene structure (upper panel) and multiple amino acid alignments (lower panel) of Tlx1. Seahorse harbors a missense mutation of A (Alanine, Ala) to T (Threonine, Thr) in the homeodomain. c Extended Data examination of the identified tlx1 mutation in 18 seahorse species. All detected seahorses exhibit T (ACT) instead of A (GCT or GCC or GCG), unlike other vertebrates. The figure was created with BioRender.com.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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