ZFIN Image: Liu et al., 2022, Fig. 2

Image

Figure Caption

Fig. 2 Seahorse-specific mutation of the tlx1 gene. Seahorse-specific mutation of the <bold><italic>tlx1</italic></bold> gene.

a Schematic diagram of the involved genes during spleen growth and morphogenesis (modified from previous studies¹⁸). Red color Tlx1, the sequence-specific variation in seahorses; RA, retinoic acid. b Gene structure (upper panel) and multiple amino acid alignments (lower panel) of Tlx1. Seahorse harbors a missense mutation of A (Alanine, Ala) to T (Threonine, Thr) in the homeodomain. c Extended Data examination of the identified tlx1 mutation in 18 seahorse species. All detected seahorses exhibit T (ACT) instead of A (GCT or GCC or GCG), unlike other vertebrates. The figure was created with BioRender.com.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.