FIGURE

Figure 3

ID

ZDB-FIG-220210-28

Publication

Karuppan et al., 2021 - Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface

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Figure 3

Validation of CNTN–amyloid interactions by biolayer interferometry. The E1 domains of APP, APLP1, and APLP2 were biotinylated in a 1:1 M ratio, immobilized onto streptavidin sensors, and titrated against varying concentrations of the FN1–FN3 region of selected CNTN proteins. One representative experiment for each series is shown in A–C, whereas a summary of the affinities measured for at least three biological replicates is shown below each curve. The plots were normalized to the maximal response. APLP1, amyloid beta precursor like protein 1; APLP2, amyloid beta precursor like protein 2; APP, amyloid precursor protein; CNTN, contactin; FN1, first FN repeat; FN3, third FN repeat.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.