FIGURE

Fig. 7

ID

ZDB-FIG-211215-7

Publication

Pero et al., 2021 - Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy

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Fig. 7

D2 accumulation is sufficient and necessary to drive defects in mitochondria motility caused by Bort. (A and C) Representative kymographs of mitochondria motility in DRG neurons infected with shCCP1 and shNC lentivirus (A) or pLVX-EGFP-D2 and WT-α-tubulin lentivirus (C) prior to infection with Mito-DsRed lentivirus and Bort treatment (A). Videos, 10 s/frame for 30 min. (B and D) Quantification of mitochondria dynamic state density in neurons treated as in A and C and expressed as a fraction of total mitochondria density. Dynamic Pause (DP); Stationary (ST); Anterograde Running (AR); Retrograde Running (RR). Data shown in B and D are from 9 to 19 (B) or 8 to 12 neurites (B) pooled from three independent experiments. All data in B and D are shown as medians plus interquartile range, and statistics were analyzed by Mann–Whitney U test. **P < 0.01, ***P < 0.001, and ****P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA