FIGURE

FIGURE 6

ID

ZDB-FIG-211004-22

Publication

Xia et al., 2021 - A Dominant Heterozygous Mutation in COG4 Causes Saul-Wilson Syndrome, a Primordial Dwarfism, and Disrupts Zebrafish Development via Wnt Signaling

Other Figures

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FIGURE 6

LGK974 treatment suppresses shortened body length and chondrocyte defect caused by of COG4^p.G516G expression in zebrafish. (A) Scheme of the LGK974 treatment procedure. (B) Graphs show the measured body length of each group at 4 dpf. The data are presented as mean ± SEM. An unpaired two-tailed t-test was used. ^∗∗∗p < 0.001; ^∗∗p < 0.01; ^∗p < 0.05; ns, not significant. (C) Ventral view of representative Meckel’s cartilage of control and COG4^p.G516G-injected embryos with or without LGK974 treatment at 4 dpf following WGA staining and imaged by a confocal microscope. (D) Graphs show the length-to-width ratio of chondrocytes in Meckel’s cartilage in (C) and two more representative Meckel’s cartilage images of each group. The data are presented as mean ± SEM. One-way ANOVA with Tukey’s multiple comparison tests was applied. ^****p < 0.0001; ^∗∗p < 0.01; ns, not significant. Experiments were performed in two biological replicates with similar results.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol