FIGURE

FIGURE 7

ID

ZDB-FIG-211004-23

Publication

Xia et al., 2021 - A Dominant Heterozygous Mutation in COG4 Causes Saul-Wilson Syndrome, a Primordial Dwarfism, and Disrupts Zebrafish Development via Wnt Signaling

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FIGURE 7

Non-canonical WNTs and related component level in SWS-derived cells. (A) qPCR analyses of selective non-canonical Wnt pathway components in SWS-derived fibroblasts. GAPDH was used as an internal control. The graphs represent the 2^–ΔΔCt values. Unpaired two-tailed t-test was applied for comparison of each SWS fibroblast with two controls. ^****p < 0.0001. Experiments were performed in triplicates with similar results. (B) Western blotting of a few Wnt pathway components. GM05565 and GM09503 are control fibroblasts. P1.1, P4.1, and P5.1 are SWS-derived fibroblasts. (C) Quantitation assay of WNT4 and pJNK band density in (B) and the other replicates. The data are presented as mean ± SEM. An unpaired two-tailed t-test was used. ^∗p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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