FIGURE

Figure 6

ID

ZDB-FIG-210915-93

Publication

Schellens et al., 2021 - Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa

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Figure 6

Histological examination of wild-type, eys^KO and eys^Δexon40-44 zebrafish retinas. Light microscopy of retinal sections from adult zebrafish (15 months post fertilization (mpf)) stained with hematoxylin (purple) and eosin (red). Retinas of the eys^Δexon40-44 and eys^KO lines are morphologically indistinguishable. In both the eys^Δexon40-44 and eys^KO retinas, a reduction of the thickness of all retinal layers was observed as compared to wild-type controls. In addition, photoreceptor outer segments seem to be shortened and disorganized in both eys^Δexon40-44 and eys^KO as compared to wild-type retinas. Scale bar: 20 μm. RPE: retinal pigment epithelium, ONL: outer nuclear layer, OPL: outer plexiform layer, INL: inner nuclear layer, GCL: ganglion cell layer.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eys^rmc9/rmc9 (TL) eys^{rmc101/rmc101} (TL)
Observed In:	eye photoreceptor cell photoreceptor outer segment retinal ganglion cell layer retinal inner nuclear layer retinal outer nuclear layer retinal outer plexiform layer retinal pigmented epithelium
Stage:	Adult

Phenotype Detail

Acknowledgments

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