FIGURE

Fig 7

ID

ZDB-FIG-210801-46

Publication

Vong et al., 2021 - The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish

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Fig 7

Loss of PGCs in MZ<italic toggle='yes'>igf2bp3</italic><sup><italic toggle='yes'>la659Tg</italic></sup> mutant embryos might arise from cell death.

A. Some PGCs are lost during migration in maternal igf2bp3^la659Tg embryos. At bud stage, a subset of PGCs labelled with a GFP-nos1 live reporter display fragmentation during migration. B. Immunofluorescence with an α-Vasa antibody and TUNEL staining showed that compared to wild type embryos, in MZigf2bp3^la659Tg embryos a subset of PGCs undergo cell death and fragmentation at the bud stage. Yellow arrow indicates co-localisation of Vasa and TUNEL labelling in a PGC, white arrows indicate Vasa+ fragments; Scale bar, 50 μm.

Expression Data

Antibody:	Ab6-ddx4
Fish:	WT igf2bp3^{la020659Tg/la020659Tg}
Anatomical Term:	primordial germ cell
Stage:	Bud

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	igf2bp3^{la020659Tg/la020659Tg}
Observed In:	primordial germ cell primordial germ cell apoptotic process
Stage:	Bud

Phenotype Detail

Acknowledgments

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