FIGURE

FIGURE 5

ID

ZDB-FIG-210718-25

Publication

Łysyganicz et al., 2021 - Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia

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FIGURE 5

Increase in mono-glycylation, but not poly-glutamination, of tubulin in triple mutant cilia. Green acetylated tubulin, red (A) poly-glutamylated tubulin (B) mono-glycylated tubulin Blue DAPI. (C,D) signals normalized to wild type. t-test ***p < 0.05. ns, no significant.

Expression Data

Antibodies:	Ab1-tub-glut Ab2-tub-glyc Ab15-tuba
Fish:	WT hdac10^sh401/sh401; hdac6^sh400/sh400; sirt2^sh626/sh626
Anatomical Terms:	anterior crista kinocilium lateral crista kinocilium posterior crista kinocilium
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hdac10^sh401/sh401; hdac6^sh400/sh400; sirt2^sh626/sh626
Observed In:	anterior crista kinocilium lateral crista kinocilium posterior crista kinocilium
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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