FIGURE

FIGURE 4

ID

ZDB-FIG-210718-18

Publication

Łysyganicz et al., 2021 - Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia

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FIGURE 4

Chemical inhibition of Hdac6. (A) Effects of 72-h treatment with 5 μM CAY-10603 hdac6 inhibitor and hdac6-/- mutation on tubulin acetylation in cristae cilia of 3 dpf old embryo. (B) Tubulin acetylation level normalized to wt. Arrowheads point cilia. (t-test ****p < 0.0001. ns, no significant. n_wt = 32 n_hdac6 = 17 n_CAY10603 = 19).

Expression Data

Antibodies:	Ab1-tub-glut Ab15-tuba
Fish:	WT hdac6^sh400/sh400
Condition:	chemical treatment by environment: EC 3.5.1.98 (histone deacetylase) inhibitor
Anatomical Terms:	anterior crista kinocilium lateral crista kinocilium posterior crista kinocilium
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT hdac6^sh400/sh400
Condition:	chemical treatment by environment: EC 3.5.1.98 (histone deacetylase) inhibitor
Observed In:	anterior crista kinocilium lateral crista kinocilium posterior crista kinocilium
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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