FIGURE

FIGURE 3

ID

ZDB-FIG-210319-62

Publication

Vishnolia et al., 2021 - sGC Activity and Regulation of Blood Flow in a Zebrafish Model System

Other Figures

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FIGURE 3

(A) Graphs represent mRNA downregulation of gucy1a1, gucy1b1, and cct7 genes using morpholino (MO) in zebrafish. No cross reactivity of morpholinos was observed between the two subunits of gucy gene in the mRNA expression. (B) Graphs represent comparison of blood flow parameters measured from gucy1a1 (n = 12), gucy1b1 (n = 12), gucy1a1+gucy1b1 (n = 12), and control-MO (n = 10). (C) Graphs presenting comparison of blood flow parameters measured from AB-wild-type (n = 10), cct7-MO (n = 12), gucy1a1^+/– (n = 12), and gucy1a1^+/– + cct7-MO (n = 12). Data are presented as mean ± standard deviation, significance was set at p < 0.05, and stars denote the significant differences.

Expression Data

Genes:	cct7 gucy1a1 gucy1b1
Fish:	AB AB + MO1-cct7 AB + MO1-gucy1b1 AB + MO2-gucy1a1
Knockdown Reagents:	MO1-cct7 MO1-gucy1b1 MO2-gucy1a1
Anatomical Term:	whole organism
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-cct7 AB + MO1-gucy1b1 AB + MO2-gucy1a1 gucy1a1^zf3477/+ (AB) gucy1a1^zf3477/+ + MO1-cct7 (AB) AB + MO1-gucy1b1 + MO2-gucy1a1
Knockdown Reagents:	MO1-cct7 MO1-gucy1b1 MO2-gucy1a1
Observed In:	blood circulation blood vessel heart contraction whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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