Gene

gucy1a1

ID

ZDB-GENE-050417-230

Name

guanylate cyclase 1 soluble subunit alpha 1

Symbol

gucy1a1 Nomenclature History

Previous Names

gucy1a3
im:7136149
zgc:112159 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable guanylate cyclase activity. Acts upstream of or within inflammatory response to wounding. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in diencephalon; floor plate; and ovary. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7136149 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gucy1a1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Moyamoya disease	Alliance	Moyamoya 6 with achalasia	615750

Associated With gucy1a1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Domain	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
Domain	IPR011645	Haem NO binding associated
Homologous_superfamily	IPR029787	Nucleotide cyclase
Homologous_superfamily	IPR038158	H-NOX domain superfamily
Homologous_superfamily	IPR042463	Haem NO binding associated domain superfamily