Gene

gucy1b1

ID

ZDB-GENE-090313-160

Name

guanylate cyclase 1 soluble subunit beta 1

Symbol

gucy1b1 Nomenclature History

Previous Names

gucy1b3
si:ch73-34b5.3

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have guanylate cyclase activity; heme binding activity; and nucleotide binding activity. Predicted to be involved in cGMP-mediated signaling and trans-synaptic signaling by nitric oxide, modulating synaptic transmission. Predicted to localize to presynaptic active zone. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Vishnolia et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gucy1b1 Human Ortholog

No data available

Associated With gucy1b1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Domain	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
Domain	IPR011644	Heme NO-binding
Domain	IPR011645	Haem NO binding associated
Homologous_superfamily	IPR024096	NO signalling/Golgi transport ligand-binding domain superfamily
Homologous_superfamily	IPR029787	Nucleotide cyclase
Homologous_superfamily	IPR038158	H-NOX domain superfamily
Homologous_superfamily	IPR042463	Haem NO binding associated domain superfamily