FIGURE

Figure 6

ID

ZDB-FIG-210301-105

Publication

Brastrom et al., 2021 - Functional Role of the RNA-Binding Protein Rbm24a and Its Target sox2 in Microphthalmia

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Figure 6

Injection of sox2 RNA can partially restore visual function by VIZN to rbm24a knockdown embryos. VIZN was performed on uninjected, rbm24a knockdown, rbm24a knockdown with sox2 RNA, and sox2 RNA larvae. Knockdown of rbm24a statistically significantly inhibits visual function when compared to uninjected. Addition of sox2 RNA to rbm24a knockdown statistically significantly improves visual function when compared to rbm24a knockdown, but not to the same level as uninjected. Injection of sox2 RNA alone does not statistically significantly alter visual function from uninjected. Mann–Whitney * p < 0.05, ** p < 0.01, **** p < 0.0001. Nonsignificant interactions not shown.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO6-rbm24a
Knockdown Reagent:	MO6-rbm24a
Observed In:	visual behavior
Stage:	Day 4

Phenotype Detail

Acknowledgments

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