FIGURE

Figure 5

ID

ZDB-FIG-201229-67

Publication

Keefe et al., 2020 - Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

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Figure 5

Determination of cell types affected in mutants by changes in proliferation or in apoptosis. (A) Confocal images of brain, z-stack, rostral to the top, in WT, eif2b5^zc103/zc103, eif2b5^zc102/zc102 or eif2b2^{sa17223/sa172233} larvae. Confocal images of brain, z-stack, rostral to the top. Top row, labeling for Zrf1, DAPI, and pH3. Middle row, labeling for HuC/D, DAPI, and pH3. Bottom row, labeling for apoeb, DAPI, and pH3. (B) Quantification of cell counts in (A). (C) Confocal images of brain, z-stack, rostral to the top, in WT, eif2b5^zc103/zc103, eif2b5^zc102/zc102 or eif2b2^{sa17223/sa172233} larvae. Confocal images of brain, z-stack, rostral to the top. Top row, labeling for Zrf1, DAPI, and TUNEL. Middle row, labeling for HuC/D, DAPI, and TUNEL. Bottom row, labeling for apoeb, DAPI, and TUNEL. (D) Quantification of cell counts in (C).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eif2b2^{sa17223/sa17223} eif2b5^zc102/zc102 eif2b5^zc103/zc103
Observed In:	axis cell population proliferation axis microglial cell axis radial glial cell brain apoptotic process microglial cell neuron cell population proliferation optic tectum cell population proliferation optic tectum neuron radial glial cell apoptotic process
Stage:	Day 5

Phenotype Detail

Acknowledgments

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