FIGURE

Fig. 1

ID

ZDB-FIG-201214-1

Publication

Stratman et al., 2020 - Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment

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Fig. 1

vSMCs associate with arteries during development.

a Schematic diagram illustrating vSMC coverage of arteries and lack of coverage of veins. b Schematic diagram of a zebrafish larva with the red box highlighting the area imaged in panel c. c Confocal micrograph of the anterior trunk of a 4 dpf Tg(tagln:eGFP), Tg(kdrl:mCherry-CAAX) double-transgenic zebrafish larva expressing eGFP in vSMCs (green) and mCherry-CAAX in the endothelium (magenta)². vSMCs are associated with the dorsal aorta (DA) and not the cardinal vein (CV). d Schematic diagram of a zebrafish larva with the red box highlighting the area imaged in panels e and f. e, f Whole mount in situ hybridization of the mid-trunk of 48 hpf zebrafish larvae probed for cxcl2b ligand (e) or cxcr4a receptor (f). Expression of both genes is enriched in the dorsal aorta compared to the cardinal vein. n = 20; scale bars = 75 µm. g Schematic representation of arterial-enriched expression of cxcl12b and cxcr4a.

Expression Data

Genes:	cxcl12b cxcr4a
Fish:	WT
Anatomical Term:	dorsal aorta
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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