Gene
cxcr4a
- ID
- ZDB-GENE-020102-1
- Name
- chemokine (C-X-C motif) receptor 4a
- Symbol
- cxcr4a Nomenclature History
- Previous Names
-
- cb824 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable chemokine receptor activity. Acts upstream of with a positive effect on G1/S transition of mitotic cell cycle and cilium assembly. Acts upstream of or within with a positive effect on Kupffer's vesicle development. Acts upstream of or within several processes, including embryonic morphogenesis; neural crest cell migration involved in sympathetic nervous system development; and vasculature development. Predicted to be located in early endosome and membrane. Is expressed in several structures, including brain; endoderm; mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 60 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb824 (27 images)
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a169 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
| s421 | unknown | Unknown | Unknown | not specified | |
| sa1098 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| um20 | Allele with one deletion | Unknown | Unknown | zinc finger nuclease | |
| um21 | Allele with one delins | Unknown | Frameshift, Premature Stop | not specified | |
| y612 | Allele with one delins | Unknown | Unknown | not specified |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| WHIM syndrome 1 | Alliance | Myelokathexis, isolated | 193670 |
| WHIM syndrome 1 | Alliance | WHIM syndrome 1 | 193670 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chemokine receptor family | CXC chemokine receptor 4/atypical chemokine receptor 2 | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZU02
|
360 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcr4a-201
(1)
|
Ensembl | 1,636 nt | ||
| mRNA |
cxcr4a-202
(1)
|
Ensembl | 1,227 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-268G8 | ZFIN Curated Data | |
| Encodes | EST | cb824 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:56609 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131882 (1) | 1536 nt | ||
| Genomic | GenBank:CU639412 (2) | 58624 nt | ||
| Polypeptide | UniProtKB:Q7ZU02 (1) | 360 aa |
- Ahuja, S., Adjekukor, C., Li, Q., Kocha, K.M., Rosin, N., Labit, E., Sinha, S., Narang, A., Long, Q., Biernaskie, J., Huang, P., Childs, S.J. (2024) The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors. PLoS Biology. 22:e3002590e3002590
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Wright, K., Han, D.J., Song, R., de Silva, K., Plain, K.M., Purdie, A.C., Shepherd, A., Chin, M., Hortle, E., Wong, J.J., Britton, W.J., Oehlers, S.H. (2024) Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection. Life science alliance. 7(4):
- Chen, J., He, J., Luo, L. (2022) The brain vascular damage-induced lymphatic ingrowth is directed by Cxcl12b/Cxcr4a. Development (Cambridge, England). 149(13)
- Das, R.N., Tevet, Y., Safriel, S., Han, Y., Moshe, N., Lambiase, G., Bassi, I., Nicenboim, J., Brückner, M., Hirsch, D., Eilam-Altstadter, R., Herzog, W., Avraham, R., Poss, K.D., Yaniv, K. (2022) Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 606(7914):570-575
- El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029
- Feng, G., Sun, Y. (2022) The Polycomb group gene rnf2 is essential for central and enteric neural system development in zebrafish. Frontiers in neuroscience. 16:960149
- Hehr, C.L., Halabi, R., McFarlane, S. (2022) Spatial regulation of amacrine cell genesis by Semaphorin 3f. Developmental Biology. 491:66-81
- Kimura, K., Yamamori, S., Hazawa, M., Kobayashi-Sun, J., Kondo, M., Wong, R.W., Kobayashi, I. (2022) Inhibition of canonical Wnt signaling promotes ex vivo maintenance and proliferation of hematopoietic stem cells in zebrafish. Stem cells (Dayton, Ohio). 40(9):831-842
- Liu, J., Zhang, M., Dong, H., Liu, J., Mao, A., Ning, G., Cao, Y., Zhang, Y., Wang, Q. (2022) Chemokine signaling synchronizes angioblast proliferation and differentiation during pharyngeal arch artery vasculogenesis. Development (Cambridge, England). 149(23):
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