FIGURE

Figure 6

ID

ZDB-FIG-201102-15

Publication

Santhanam et al., 2020 - A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors

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Figure 6

Continuous cell proliferation in the P23H transgenic zebrafish. Wholemount imaging of BrdU (red) labeled cells in ONL of the WT (A,B) and P23H transgenic (C,D) 5 and 24 h after BrdU injection respectively. Retp1 (green) labels rhodopsin. Yellow arrowheads in panel D show BrdU-labeled cells that co-label with Retp1, indicating their differentiation into rods. Scale bar in B applies to A–D. (E) The number of BrdU-labeled cells in the P23H transgenic fish is significantly higher than in the WT (n = 3 fish per genotype; error bars are ± SD; *** p < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	uth4Tg (AB)
Observed In:	retinal outer nuclear layer cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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