FIGURE

Figure 7

ID

ZDB-FIG-201003-47

Publication

Zhang et al., 2020 - An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway

Other Figures

All Figure Page

Back to All Figure Page

Figure 7

Mechanistic model to show how MEQ inhibits triple-negative breast cancer (TNBC) angiogenesis by regulating the MTA2/SerRS/VEGFA axis. The MTA2-containing NuRD deacetylase complex binds to the SerRS promoter to suppress its transcription, which allows more SerRS competitor, i.e., c-Myc proteins, to bind to the VEGFA promoter and activate VEGFA expression and tumor angiogenesis. MEQ interacts with MTA2 and may cause the release of the NuRD complex from the SerRS promoter, resulting in elevated expression of SerRS, which competes off the c-Myc and binds to the VEGFA promoter to suppress its transcription and inhibit tumor angiogenesis.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @