FIGURE

Fig 6

ID

ZDB-FIG-200718-33

Publication

Deveau et al., 2020 - Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

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Fig 6

<italic>6BP+1</italic> larval cone PIII ERG spectral response traces.

(A) The 6BP+1 mutant does not respond to 650 nm and 570 nm while maintaining a response to shorter wavelengths (N = 12, 70-point datasets). (B) The heterozygote shows sustained responses across all wavelengths (650–330 nm) (N = 16, 70-point datasets). Only half of the spectral dataset is shown in A and B. Wavelength brightness is given in log units of stimulus attenuation, with 5.0 log units being the dimmest stimulus corresponding to the lowest amplitude response, and 2.0 log units being the brightest stimulus corresponding to the largest amplitude response. Larvae are 5 dpf. Cone PIII responses are isolated with 20 mM Na Aspartate.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	thrb^nds2/nds2 thrb^nds2/+
Observed In:	retinal cone cell response to red light
Stage:	Day 5

Phenotype Detail

Acknowledgments

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