FIGURE

Figure 8

ID

ZDB-FIG-200711-9

Publication

Sun et al., 2020 - Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling

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Figure 8

Fgfr3 mutation promotes chondrocyte proliferation and inhibits osteoblast proliferation. (A) Edu incorporation assay in WT and fgfr3 mutants of Tg(osterix:EGFP) background at 1 month (SL 10.0 mm), (B) is the higher magnification of ceratohyal cartilage. White arrows indicate the increased proliferation of chondrocytes in ceratohyal cartilage of fgfr3 mutants. (C) Quantification of the proliferation ratio of osterix labeled osteoblasts in (A), n = 10, *p < 0.05. (D) Quantification of the proliferation ratio of chondrocytes in ceratohyal cartilage in (A), n = 10, **p < 0.01. Scale bars: 100 µm in A.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgfr3^{zf3388/zf3388} (AB) fgfr3^{zf3389/zf3389} (AB)
Observed In:	chondrocyte proliferation osteoblast proliferation
Stage:	Days 30-44

Phenotype Detail

Acknowledgments

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