FIGURE

Figure 6

ID

ZDB-FIG-200711-7

Publication

Sun et al., 2020 - Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling

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Figure 6

The phenotype of fgfr3 mutant zebrafish detected by Alizarin red and Alcian blue whole skeleton staining. (A, C) Alizarin red and Alcian blue whole skeleton staining of the WT and fgfr3 mutant at 20 dpf (SL 7.5 mm) (A) and 30 dpf (SL 10.0 mm) (C). Left two panels show the lateral view and dorsal view of the craniofacial bone. Right two panels show the dissected pharyngeal arches and the magnified ceratohyal bone. (B, D) Quantification of ceratohyal cartilage length for WT and fgfr3 mutants at 20 dpf (SL 7.5 mm) (B) and 30 dpf (SL 10.0 mm) (D). n = 6, *p<0.05, no significance (ns). (E) Lateral view (left) and ventral view (right) of the Weberian apparatus of the WT and fgfr3 mutant at 30 dpf (SL 10.0 mm). Ch: ceratohyal cartilage. Scale bar, 200 µm in A, C and E.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgfr3^{zf3388/zf3388} (AB) fgfr3^{zf3389/zf3389} (AB)
Observed In:	basihyal bone basihyal cartilage ossification branchiostegal ray branchiostegal ray ossification ceratobranchial cartilage endochondral ossification ceratohyal bone ceratohyal cartilage claustrum bone claustrum cartilage ossification dentary dentary intramembranous ossification hypobranchial bone hypobranchial cartilage endochondral ossification intercalarium intercalarium ossification opercle opercle intramembranous ossification palatoquadrate cartilage endochondral ossification pharyngeal arch 1 pharyngeal arch 2 retroarticular retroarticular endochondral ossification scaphium scaphium ossification tripus tripus ossification
Stage Range:	Days 14-20 to Days 30-44

Phenotype Detail

Acknowledgments

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