FIGURE

Fig. 2

ID

ZDB-FIG-200326-45

Publication

Jurynec et al., 2019 - The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors

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Fig. 2

Zygotically supplied Paf1 is not required for the initial induction or specification of the premigratory NC, but is required at later stages for development of the full premigratory and migrating NC population. Gene expression detected by whole-mount in situ hybridization in 11-11.5 hpf (A-D), 11.5-12 hpf (E-J), 12-12.5 hpf (K-N) and 16 hpf (O-V) wild-type sibling and alnz24 mutant embryos. Expression of msx1b (A,B), pax3a (C,D), dlx3b (E,F), tfap2a (G,H) and sox10 (I,J) is similar in alnz24 mutants and wild-type siblings. A slight decrease in foxd3 (K,L) and snai1b (M,N) expression is detected in alnz24 embryos when compared with wild-type siblings. Expression of foxd3 (O,P), crestin (Q,R), snai1b (S,T) and sox10 (U,V) are all reduced or absent in the trunk region of 16 hpf alnz24 mutant embryos. A-N are dorsal views with anterior towards the left. O-V are lateral views with anterior towards the left. Arrowheads indicate premigratory NC.

Expression Data

Genes:	crestin dlx3b foxd3 msx1b pax3a snai1b sox10 tfap2a
Fish:	WT paf1^z24/z24
Anatomical Terms:	neural crest neural plate border
Stage Range:	1-4 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	paf1^z24/z24
Observed In:	neural crest
Stage Range:	5-9 somites to 14-19 somites

Phenotype Detail

Acknowledgments

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