FIGURE

Figure 9

ID

ZDB-FIG-200325-42

Publication

Zambusi et al., 2020 - Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon

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Figure 9

Grna and Grnb deficiency causes downregulation of telomere-protective genes and telomere shortening in the telencephalon in young zebrafish, as observed in old animals. (a) Histogram depicting normalised gene counts of tert, tp53, and tpp1. (b) Histogram depicting relative telomere length in the young wildtype, old wildtype, young mutant, and old mutant zebrafish telencephalon. n.s not significant, * padj ≤ 0.05, ** padj ≤ 0.01, *** padj ≤ 0.001, **** padj ≤ 0.0001, each data point represents a distinct biological replicate (five telencephali per group were analysed).

Expression Data

Genes:	tert tp53 tpp1
Fish:	grna^{mde54a/mde54a}; grnb^{mde360/mde360}
Anatomical Term:	telencephalon
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	grna^{mde54a/mde54a}; grnb^{mde360/mde360}
Observed In:	telencephalon telencephalon chromosome, telomeric region
Stage:	Adult

Phenotype Detail

Acknowledgments

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