FIGURE

Figure 4

ID

ZDB-FIG-200314-71

Publication

Kang et al., 2020 - Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network

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Figure 4

GCGR regulate lipid metabolism in zebrafish larva. (A–C) Heatmaps of transcripts in lipid metabolism enrichment (A) in peroxisome proliferator-activated receptors (PPAR) pathway enrichment (B) and in mitogen-activated protein kinase (MAPK) pathway enrichment (C). Colors represent high (red), low (blue), or average (white) expression values based on Z-score normalized fragments per kilo base per million mapped reads (FPKM) values for each gene. The Z-score indicators are shown under each map. The fold change (log2) are shown on the right. (D–G) Oil Red O (ORO) staining of 7 dpf wildtype (F) and gcgr^−/− (G) mutant larvae. Whole-mount ORO staining (D,F) and liver frozen sections ORO staining (E,G) both show accumulation of lipids in the mutant liver. Yellow dash line indicates the liver area.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gcgra^vu600/vu600; gcgrb^vu601/vu601
Observed In:	liver lipid
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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