ZFIN Image: Kang et al., 2020, Figure 4

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Figure Caption

Figure 4

GCGR regulate lipid metabolism in zebrafish larva. (A–C) Heatmaps of transcripts in lipid metabolism enrichment (A) in peroxisome proliferator-activated receptors (PPAR) pathway enrichment (B) and in mitogen-activated protein kinase (MAPK) pathway enrichment (C). Colors represent high (red), low (blue), or average (white) expression values based on Z-score normalized fragments per kilo base per million mapped reads (FPKM) values for each gene. The Z-score indicators are shown under each map. The fold change (log2) are shown on the right. (D–G) Oil Red O (ORO) staining of 7 dpf wildtype (F) and gcgr^−/− (G) mutant larvae. Whole-mount ORO staining (D,F) and liver frozen sections ORO staining (E,G) both show accumulation of lipids in the mutant liver. Yellow dash line indicates the liver area.

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Phenotype details

Acknowledgments

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