FIGURE

Fig. S2

ID

ZDB-FIG-190814-10

Publication

Shim et al., 2019 - Pathway-specific protein domains are predictive for human diseases

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Fig. S2

In vivo validation of candidate coronary artery disease (CAD) genes.

(a) The sequence of translation-blocking MOs targeting candidate CAD genes used for this study. (b) Tg(flk1:EGFP) zebrafish embryos were injected with morpholinos (MOs) for candidate CAD genes and compared with control MO-injected embryos (morphants). The majority of morphants, except for apod morphants, exhibit gross morphological abnormalities, including a small brain, heart edema, and curved tail, at 3 days post-fertilization (scale bar = 500 μm). (c) Diagrams show the representative heart defects, such as no asymmetry (midline) and reversed asymmetry between ventricle and atrium, at 3 days post-fertilization.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg + MO1-apoda.2 s843Tg + MO1-atp2a2b s843Tg + MO1-slc22a2 s843Tg + MO1-tram1 s843Tg + MO3-cyp11a1.1
Knockdown Reagents:	MO1-apoda.2 MO1-atp2a2b MO1-slc22a2 MO1-tram1 MO3-cyp11a1.1
Observed In:	determination of heart left/right asymmetry heart
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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