FIGURE

Fig. 6

ID

ZDB-FIG-190617-8

Publication

Bose et al., 2018 - Neuromuscular junction abnormalities in a zebrafish loss-of-function model of TDP-43

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Fig. 6

A: 5 superimposed locomotor path traces of 48-h postfertilization (hpf) het/hom mutants without and with chronic application of BAY K 8644 (2 μM). B–D: swim duration (B), swim distance (C), and maximum velocity (D) were measured at 48 hpf in WT and het/hom mutants after chronic application of BAY K 8644 (2 μM) in the touch-evoked escape response (TEER) assay. het/hom mutants with treatment displayed significant recovery from locomotor defect in swim duration and swim distance of the TEER assay compared with het/hom mutants without treatment (paired t-test; P < 0.01). E: recordings of miniature end-plate currents (mEPCs) from 2-day postfertilization (dpf) het/hom mutants after chronic application of BAY K 8644 (2 μM). het/hom mutants showed a significant recovery in mEPC frequency (paired t-test; **P < 0.01). F and G: distance swam (F) and mean velocity (G) at 5 dpf by het/hom mutants untreated and treated with BAY K 8644 (2 μM) for 4 days. **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT tardbpb^fh301/+; tardbpa^{udm104/udm104}
Condition:	chemical treatment by environment: Bay-K-8644
Observed In:	fast muscle cell mini excitatory postsynaptic potential fast muscle cell neuromuscular synaptic transmission swimming
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurophysiol.