FIGURE

Fig. 3

ID

ZDB-FIG-190617-6

Publication

Bose et al., 2018 - Neuromuscular junction abnormalities in a zebrafish loss-of-function model of TDP-43

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Fig. 3

Significant locomotor and coiling defects in hom/hom mutants. A and B: burst count per minute (A) and burst duration (B) were measured for the following different genotypes: wild type (WT), tardbp^−/−, tardbpl^−/−, het/hom, and hom/hom at 17 h postfertilization (hpf). hom/hom mutants show a significantly reduced burst count per minute compared with all the other different genotypes. C: 4 superimposed locomotor path traces of 48-hpf larvae from the following different genotypes: WT, tardbp^−/−, tardbpl^−/−, het/hom, and hom/hom. D–F: swim duration (D), swim distance (E), and maximum velocity (F) were measured for each treatment group in the touch-evoked escape response (TEER) assay. hom/hom mutants displayed significant locomotor defect in all parameters of the TEER assay compared with all other different genotypes (**P < 0.01). Additionally, het/hom mutant larvae also showed significantly reduced swim distance compared with WT, tardbp^−/−, and tardbpl^−/− larvae (*P < 0.05). Numbers in parentheses indicate sample sizes for the TEER assay in each treatment group. Data are means ± SE.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tardbpa^{udm104/udm104} tardbpb^fh301/fh301 tardbpb^fh301/+; tardbpa^{udm104/udm104} tardbpb^fh301/fh301; tardbpa^{udm104/udm104}
Observed In:	musculoskeletal movement swimming
Stage Range:	14-19 somites to Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurophysiol.