FIGURE

Fig. 2

ID

ZDB-FIG-190528-3

Publication

Bose et al., 2018 - Neuromuscular junction abnormalities in a zebrafish loss-of-function model of TDP-43

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Significant morphological defects and reduced survival in hom/hom mutants. A: images of 48-h postfertilization larvae of the following different genotypes: wild type (WT), tardbp^−/−, tardbpl^−/−, het/hom, and hom/hom. Scale bar, 1 mm. Arrow indicates inflated pericardium in het/hom and hom/homlarvae. B–D: body length (B), eye diameter (C), and pericardial area (D) were measured for each treatment group. hom/hom mutants displayed significantly reduced body length and eye diameter and increased pericardial area (**P < 0.01). Additionally, het/hom larvae also displayed a significantly increased pericardial area (*P < 0.05). E: percent survival of WT, tardbp^−/−, tardbpl^−/−, het/hom, and hom/hommutant larvae tracked for 12 days. All hom/hom mutants died between 4 and 6 days (P < 0.01). Data are means ± SE; N = 2, n = 62. Numbers in parentheses indicate sample sizes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tardbpa^{udm104/udm104} tardbpb^fh301/fh301 tardbpb^fh301/+; tardbpa^{udm104/udm104} tardbpb^fh301/fh301; tardbpa^{udm104/udm104}
Observed In:	eye heart whole organism
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurophysiol.