FIGURE

Fig. 1

ID

ZDB-FIG-190328-16

Publication

Park et al., 2018 - Zebrafish model of KRAS-initiated pancreatic cancer

Other Figures

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Fig. 1

Identification of tge PanIN region in Tg (ptf1a:CRE^ERT2; LSL-GAL4; UAS-KRAS^G12V) fish. (A) Schematic of the ptf1a CRE-driver line,Tg (ptf1a:CRE^ERT2), the CRE-responder line Tg (LSL-GAL4), and the GAL4-responder line Tg (UAS-KRAS^G12V). (B) Quantiﬁcation of PanIN induction frequency in Tg (ptf1a:CRE^ERT2; LSL-GAL4; UAS-KRAS^G12V) fish. (C) Dissected abdominal viscera with an eGFP-positive tumor from KRAS^G12V. Scale bars: 2 mm. (D–F) The histological profiles of tumors bear striking resemblance to human PanIN. Boxed areas indicate regions depicted at higher magnification in adjacent images. Scale bars: 50 μm. (G) Quantiﬁcation of PanIN region vs. total pancreatic area in Tg (ptf1a:CRE^ERT2; LSL-GAL4; UAS-KRAS^G12V) fish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mk201Tg; mk202Tg; zf2157Tg
Condition:	chemical treatment by environment: afimoxifene
Observed In:	pancreas pancreas infiltrating duct carcinoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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