ZFIN Image: Park et al., 2018, Fig. 1

Image

Figure Caption

Fig. 1

Identification of tge PanIN region in Tg (ptf1a:CRE^ERT2; LSL-GAL4; UAS-KRAS^G12V) fish. (A) Schematic of the ptf1a CRE-driver line,Tg (ptf1a:CRE^ERT2), the CRE-responder line Tg (LSL-GAL4), and the GAL4-responder line Tg (UAS-KRAS^G12V). (B) Quantiﬁcation of PanIN induction frequency in Tg (ptf1a:CRE^ERT2; LSL-GAL4; UAS-KRAS^G12V) fish. (C) Dissected abdominal viscera with an eGFP-positive tumor from KRAS^G12V. Scale bars: 2 mm. (D–F) The histological profiles of tumors bear striking resemblance to human PanIN. Boxed areas indicate regions depicted at higher magnification in adjacent images. Scale bars: 50 μm. (G) Quantiﬁcation of PanIN region vs. total pancreatic area in Tg (ptf1a:CRE^ERT2; LSL-GAL4; UAS-KRAS^G12V) fish.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Animal Cells Syst (Seoul)