FIGURE

Fig. 8

ID

ZDB-FIG-180620-8

Publication

Gou et al., 2018 - sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear

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Fig. 8

Pax2a is required for prosensory but not proneural expansion. (A–H) Dorsolateral views (anterior to the left) showing otic expression of atoh1a (A–D) and neurog1 (E–H) at 24 hpf in control embryos (A, E), pax2a-morphants (C, G), hs:sox2/hs:sox2 homozygotes (B, F) and hs:sox2/hs:sox2 homozygotes injected with pax2a-mo (D, -H). Embryos were heat shocked at 12.5 hpf, 39 °C for 60 min. Otic vesicle borders are outlined in all images.

Expression Data

Genes:	atoh1a neurog1
Fish:	x21Tg/x21Tg (AB) AB x21Tg/x21Tg + MO1-pax2a + MO4-tp53 (AB) AB + MO1-pax2a + MO4-tp53
Condition:	heat shock
Knockdown Reagents:	MO1-pax2a MO4-tp53
Anatomical Term:	otic vesicle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	x21Tg/x21Tg (AB) x21Tg/x21Tg + MO1-pax2a + MO4-tp53 (AB)
Condition:	heat shock
Knockdown Reagents:	MO1-pax2a MO4-tp53
Observed In:	otic vesicle
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Vemaraju, S., Sweet, E.M., Kwon, H.J., Riley, B.B., sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear, 73-83, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.