FIGURE

Fig. 5

ID

ZDB-FIG-180620-50

Publication

Cai et al., 2018 - Knockout of zebrafish interleukin 7 receptor (IL7R) by the CRISPR/Cas9 system delays retinal neurodevelopment

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Fig. 5

Retinal development following il7r knockout.

a-d HE staining and magnified images of retinas from wild-type (WT, a and b) and il7r^−/− (c and d) embryos at 72 hpf. e–h Images of Zpr1 or Zpr3 immunofluorescence staining of retinas in WT (e and f) and il7r^−/− (g and h) embryos at 72 hpf. i-j Statistical analysis of Zpr1-positive signals (i) and Zpr3-positive signals (j) between WT and il7r^−/− retinas. Note that the Zpr1-positive area (i) and Zpr3-positive area (j) are significantly decreased in il7r^−/− retinas. Results are represented as means ± SEM (n = 10), **P < 0.01, ***P < 0.001. Scale bar: a and c, 40 μm; b and d, 10 μm; e–h, 50 μm. GCL ganglion cell layer, INL inner nuclear layer, ONL outer nuclear layer, ON optic nerve

Expression Data

Antibodies:	zpr-1 zpr-3
Fish:	TU il7r^nku2/nku2
Anatomical Term:	retinal outer nuclear layer
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	il7r^nku2/nku2
Observed In:	neural retina development retina cell retinal ganglion cell layer retinal inner nuclear layer retinal outer nuclear layer
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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