FIGURE

Fig. S1

ID

ZDB-FIG-180129-11

Publication

Giger et al., 2017 - Endodermal germ-layer formation through active actin-driven migration triggered by N-cadherin

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Fig. S1

Cell-autonomous and non–cell-autonomous effects in endoderm internalization. (A and B) Internalization of endodermal cells expressing Lifeact-GFP transplanted to the margin of a wild-type host embryo expressing membrane-bound mCherry. Arrowheads point to cytoplasmic extensions. Sagittal view, animal pole is to the top. (A′ and B′) Tracks of the movement of transplanted cells (colored arrows) and neighboring cells (gray arrows). The length of the arrows represents the instant speed. The color code represents the correlation of the instant displacement of the transplanted endodermal cell with the mean instant displacement of four neighboring cells. (A and A′) Coordinated internalization movement (Movie S3). (B and B′) Uncoordinated internalization movement (Movie S4). (C) When transplanted into a wild-type host, noninternalizing (MZoep) cells are driven into the hypoblast by their neighbors (Movie S5). (D) When transplanted into a nongastrulating (MZoep) host embryo, wild-type endodermal cells internalize autonomously, using actin-rich protrusions and rapid migration (Movie S6). (Scale bars: 10 µm.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA