FIGURE

Fig. 8

ID

ZDB-FIG-170822-16

Publication

Kroeger et al., 2017 - The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

zepandbrca2^ZM_00057434fail to complement one another. (A) Gene expression analysis of the interrenal marker nr5a1a in WT, zep -/-, brca2^ZM_00057434 -/- and compound heterozygous brca2^ZM_00057434+/-; zep +/- mutants revealed that brca2^ZM_00057434 -/- have a modest but (B) statistically significant elevation in the area of nr5a1a expression that was similar to compound heterozygous embryos. Embryos are shown in dorsal views with insets showing digital zoom of 150%, where black boxes demarcate the cervical region where the interrenal gland develops. Asterisks (*) indicate p < 0.05, (**) p < 0.01 using student T-test.

Expression Data

Gene:	nr5a1a
Fish:	WT brca2^{zf1074/zf1074} brca2^{zm00057434Tg/zm00057434Tg} brca2^zf1074/+; brca2^{zm00057434Tg/+}
Anatomical Term:	interrenal primordium
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	brca2^{zf1074/zf1074} brca2^{zm00057434Tg/zm00057434Tg} brca2^zf1074/+; brca2^{zm00057434Tg/+}
Observed In:	interrenal primordium pronephric glomerulus development
Stage:	Prim-25

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 428(1), Kroeger, P.T., Drummond, B.E., Miceli, R., McKernan, M., Gerlach, G.F., Marra, A.N., Fox, A., McCampbell, K.K., Leshchiner, I., Rodriguez-Mari, A., BreMiller, R., Thummel, R., Davidson, A.J., Postlethwait, J., Goessling, W., Wingert, R.A., The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development, 148-163, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.