FIGURE

Fig. 3

ID

ZDB-FIG-170822-11

Publication

Kroeger et al., 2017 - The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development

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Fig. 3

zepmutants show normal tubule development and fail to form a normal glomerulus. (A) WT and zep mutant embryos exhibit similar pairs of nephron tubules, which (B) are not statistically different in length. Embryos are shown in dorsal views. (C) Histological analysis of cross-sections (top, dorsal and bottom, ventral) from the cervical region of WT and zep embryos at 5 dpf. zep lack a midline glomerulus (G) ventral to the notochord (N), and the flanking tubules (T) are distended compared to WTs, consistent with the morphological appearance of edema. Black dotted lines outline the approximate perimeters of the indicated structures.

Expression Data

Genes:	cdh17 wt1b
Fish:	WT brca2^{zf1074/zf1074}
Anatomical Terms:	pronephric duct pronephric podocyte pronephric tubule
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	brca2^{zf1074/zf1074}
Observed In:	pronephric glomerulus development pronephric podocyte pronephric tubule
Stage Range:	Prim-5 to Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 428(1), Kroeger, P.T., Drummond, B.E., Miceli, R., McKernan, M., Gerlach, G.F., Marra, A.N., Fox, A., McCampbell, K.K., Leshchiner, I., Rodriguez-Mari, A., BreMiller, R., Thummel, R., Davidson, A.J., Postlethwait, J., Goessling, W., Wingert, R.A., The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development, 148-163, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.