FIGURE

Fig. S4

ID

ZDB-FIG-170502-9

Publication

Zhang et al., 2017 - Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

Other Figures

All Figure Page

Back to All Figure Page

Fig. S4

Overexpression of Gab2wt increases the number of MYCN–induced hyperplastic neuroblasts in the interrenal gland (IRG). Related to Figure 4

(A) Sagittal sections through the IRGs of MYCN and MYCN;Gab2wt transgenic fish at 5 wpf (dorsal up, anterior left). GFP, green; DAPI, blue; Merge, combined green and blue. GFP+ hyperplastic neuroblasts were indicated by brackets. Dotted lines indicate the head-kidney (HK) boundary. Wpf, weeks postfertilization. Scale bar, 20 μm.

(B) Numbers of GFP+ sympathetic neuroblasts in the IRG regions of MYCN and MYCN;Gab2wt transgenic fish at 5 wpf. Mean values (horizontal bars) were compared by Welch t-test (two-tailed). GFP+ cell numbers are significantly increased in the MYCN;Gab2wt fish as compared to those in the MYCN-only fish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.