FIGURE

Fig. 5

ID

ZDB-FIG-170502-4

Publication

Zhang et al., 2017 - Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

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Fig. 5

Overexpression of Ptpn11mut Inhibits the Developmentally Timed Apoptotic Response Triggered by MYCN Overexpression in the IRG

(A) Sagittal sections through the IRG of MYCN (top) and MYCN;ptpn11mut (bottom) transgenic fish at 5.5 wpf (dorsal up, anterior left). GFP, green; activated caspase-3, red; DAPI, blue. Arrowheads point to the activated caspase-3+ apoptotic cells. Dotted lines indicate the head kidney (HK) boundary. Scale bars, 10 μm.

(B) Percentage of activated caspase-3+ apoptotic cells to the total number of GFP+ sympathetic neuroblasts in the IRG of MYCN and MYCN;ptpn11mut fish at 5.5 wpf. Mean values (horizontal bars) were compared by the Welch t test (two-tailed).

Expression Data

Gene:	EGFP
Antibody:	Ab1-casp3
Fish:	zdf16Tg (AB) zdf16Tg; zf738Tg (AB)
Anatomical Term:	interrenal gland neuroblast
Stage:	Days 30-44

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zdf16Tg; zf738Tg (AB)
Observed In:	interrenal gland neuron apoptotic process
Stage:	Days 30-44

Phenotype Detail

Acknowledgments

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