FIGURE

Fig. 1

ID

ZDB-FIG-161027-9

Publication

Cox et al., 2016 - Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

Other Figures

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Fig. 1

seph mutant zebrafish exhibit defects in organ development. (A) Schematic illustrating the nature of the seph mutant. (B) Survival of WT and homozygous seph mutant larvae over time. n = 160 larvae. (C) Morphological assessment and fluorescent imaging (lateral and ventral views) of WT and seph mutant larvae on a Tg(ela3l:GFP;fabp10a:dsRed) background by confocal tomography at 5 dpf. Liver volume: WT, 3.09e⁶ µm³; seph, 1.69e⁶ µm³. Pancreas volume: WT, 2.79e⁶ µm³; seph, undetectable. (Scale bar: 100 µm.) (D) Quantitative analysis of fluorescent liver area in WT and seph mutant larvae at 5 dpf. n = 16. ****P < 0.0001. (E) Quantitative analysis of fluorescent pancreas area in WT and seph mutant larvae at 5 dpf. n = 16. ****P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	selenoh^{hi2737Tg/hi2737Tg} selenoh^{hi2737Tg/hi2737Tg}; gz15Tg
Observed In:	eye liver pancreas swim bladder whole organism
Stage Range:	Day 5 to Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA