FIGURE

Fig. S5

ID

ZDB-FIG-161027-15

Publication

Cox et al., 2016 - Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

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Fig. S5

The seph mutant phenotype is partially mitigated by loss of p53. (A) WISH analysis of elavl3 (neurons) expression and Alcian blue staining in WT, seph^-/-, and tp53^-/-;seph^-/- mutant larvae at 5 dpf. (Scale bar: 200 µm.) (B) qPCR expression analysis of the neuron-specific gene elavl3 in WT, tp53^-/-, and tp53^-/-;seph^-/- mutant larvae at 5 dpf. n = 3. **P < 0.01. (C) Immunohistochemical detection of PCNA (proliferation) from transverse sections from WT, seph^-/-, and tp53^-/-;seph^-/- mutant larvae at 5 dpf. (Scale bar: 50 µm.) (D) Immunohistochemical detection of cleaved caspase-3 (apoptosis) from transverse sections from WT, seph^-/-, and tp53^-/-;seph^-/- mutant larvae at 5 dpf. (Scale bar: 50 µm.)

Expression Data

Gene:	elavl3
Fish:	AB selenoh^{hi2737Tg/hi2737Tg} tp53^zdf1/zdf1; selenoh^{hi2737Tg/hi2737Tg}
Anatomical Terms:	neuron whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	selenoh^{hi2737Tg/hi2737Tg} tp53^zdf1/zdf1; selenoh^{hi2737Tg/hi2737Tg}
Observed In:	cartilage development embryonic viscerocranium morphogenesis neuron whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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