Fig. 1
- ID
- ZDB-FIG-160831-9
- Publication
- Xu et al., 2016 - Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine
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Microglial Precursors Enter the Optic Tectum via Two Major Routes (A) Coronal (top) and transverse (bottom) views of time-lapse imaging pictures of the midbrain of Tg(-2.8elavl3:eGFP;coro1a:DsRedx) zebrafish embryos indicate one microglia (marked by white arrow) entering the optic tectum from the lateral periphery of the brain. The optic tectum and eyes are indicated by white dashed lines. Red and green signals represent coro1a-DsRedx+ microglia and elavl3-GFP+ neurons, respectively. E, eye; OT, optic tectum. (B) Coronal (top) and transverse (bottom) views of time-lapse imaging pictures of the midbrain of Tg(-2.8elavl3:eGFP;coro1a:DsRedx) zebrafish embryos show one microglia (marked by the white arrow) entering the optic tectum by passing through the ventral part of the midbrain. The optic tectum and eyes are indicated by white dashed lines. Red and green signals represent coro1a-DsRedx+ microglia and elavl3-GFP+ neurons, respectively. E, eye; OT, optic tectum. (C) A schematic diagram of the transverse plane to illustrate the entry routes for the colonization of the optic tectum by microglial precursors. Route 1, the lateral periphery of the brain; route 2, passing through the ventral part of the midbrain; route 3, the dorsal periphery of the brain. See also Figure S1 and Movie S1. |
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| Stage: | Pec-fin |
Reprinted from Developmental Cell, 38(2), Xu, J., Wang, T., Wu, Y., Jin, W., Wen, Z., Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine, 214-22, Copyright (2016) with permission from Elsevier. Full text @ Dev. Cell