FIGURE

Fig. 3

ID

ZDB-FIG-160208-33

Publication

Shen et al., 2015 - Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish

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Fig. 3

Cilia damage in Msrb3 morphants. (A-D) Stereocilia in zebrafish inner ear marked with FITC-labeled phalloidin (confocal microscopy). Stereocilia in msrb3 morphants (In2MO, Ex2MO) were shorter and thinner than those of mismatch controls (In2Con, Ex2Con). In addition, msrb3 morphants had malformed semicircular canals. Scale bars: 30 µm. (E-H) Kinocilia in lateral line neuromasts of morphants were damaged (not see in controls). Scale bars: 10 µm. (I) Statistical analysis of inner ear stereocilia in controls and msrb3 morphants, “n” represents fish number. Error bars are s.d. ***P<0.0001. (J) Statistical analysis of neuromast kinocilia in controls and msrb3 morphants, “n” represents neuromasts number. Error bars are s.d. ***P<0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-msrb3 AB + MO2-msrb3
Knockdown Reagents:	MO1-msrb3 MO2-msrb3
Observed In:	inner ear stereocilium neuromast kinocilium semicircular canal
Stage:	Day 5

Phenotype Detail

Acknowledgments

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